ORCA-Fusion BT Digital CMOS camera C15440-20UP

c15440-20up product photo
Catalog (For lifescience) [5 MB/PDF]
Technical note [1 MB/PDF]

The ORCA-Fusion BT camera is the pinnacle of scientific CMOS (sCMOS) performance. The specifications are without compromise: ultra-low readout noise, CCD-like uniformity, fast frame rates and back-thinned enabled high QE. But the beauty of the ORCA-Fusion BT is what this combination of exceptional photon detection and collection can do for you. See the dimmest whisper of signal, acquire visually stunning, high S/N images from the fewest photons, capture previously unresolved temporal events and perform computational methods with confidence. The ORCA-Fusion BT is the camera that makes the difficult experiments easy and previously impossible experiments possible.

Special sites

The scientific camera section is the feature section for digital cameras fit to life science research and industry areas.

Special site for Scientific cameras

ORCA-Fusion BT advantages versus other BT CMOS cameras

Exclusive industry leading BT sCMOS performance with trusted Hamamatsu quality and reliability

  • Extremely low readout noise
  • High QE, across a wide range of wavelengths
  • CCD-like uniformity; minimal high readout noise pixels
  • High dynamic range
  • 3 readout speeds
  • Lightsheet readout mode
  • 5.3 Megapixels
  • Both USB 3.0 and high speed CoaXPress interfaces

ORCA-Fusion BT advantages versus EM-CCD cameras

A practical and functional replacement for expensive EM-CCDs with uncompromising sensitivity, speed and versatility

  • Resolution
  • Binning versatility
  • No amplification or excess noise
  • High dynamic range
  • Large field of view


  • Wide-field fluorescence microscopy
  • Time-lapse imaging
  • Spinning disk confocal microscopy
  • Lightsheet microscopy
  • Super resolution precision localization
  • Genetically encoded voltage imaging
  • Optogenetics
  • Single molecule tracking
  • Computational imaging
  • Quantum computing

Time-lapse live cell imaging by low light excitation

Sample: H9c2, Objective lens: Apo TIRF 60XC (NA1.49), ND: 8, Interval: 15 sec


c15440-20up Application example 1

HCS NuclearMask Stains / Exposure 20 ms


c15440-20up Application example 3

MitoTracker / Exposure 500 ms


c15440-20up Application example 2

CellMask Plasma Membrane stains / Exposure 500 ms

Lightsheet Readout Mode [Patented]

“Lightsheet Readout Mode” is a unique and patented feature of Hamamatsu sCMOS cameras which can improve signal to noise ratios in Lightsheet microscopy.
For more information about the principle and features of Lightsheet Readout Mode, please see details from below.

What is Lightsheet Readout Mode?

Lightsheet Readout Mode

PC recommendation

With the introduction of the ORCA-Fusion BT, users are now able to stream 5 megapixel images to their computers 89 frames per second. The computer recommendations for this high data rate can be met by using the guidelines listed this PC Recommendations for ORCA-Fusion BT.


Type number C15440-20UP
Quantum efficiency @550 nm: 95 %
Imaging device sCMOS
Effective no. of pixels 2304 (H) × 2304 (V)
Cell size 6.5 μm (H) × 6.5 μm (V)
Readout speed Fast scan: 89.1 frames/s (@2304 x 2304 pixels, 16 bit)
Readout noise Ultra-quiet scan: 0.7 electrons rms (Typ.)
Dynamic range 21 400:1 (Typ.)
A/D converter 16 bit, 12 bit, 8 bit

Spectral response

c15440-20up Spectral response


c15440-20up dimensional outline

Instruction manual

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Disclaimer [66 KB/PDF]

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